Mutant Bordetella strains and methods of use
AssigneesInstitut Pasteur de Lille, Institut National De La SantéEt De La Recherche MéDicale
InventorsLuis Solans, Camille Locht, Anne Tsicopoulos, Saliha Ait-Yahia Sendid
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Abstract
A method of reducing or preventing the development of airway inflammation in a subject includes the step of infecting the respiratory tract of a subject an amount of a composition including a pharmaceutically acceptable carrier and live attenuated pertactin-deficient Bordetella bacteria sufficient to colonize the respiratory tract of the subject. The step of infecting the subject with the live attenuated pertactin-deficient Bordetella bacteria results in reduction or prevention of the development of airway inflammation in the subject.
Claims11
A method of reducing or preventing the development of allergic airway inflammation in a subject sensitized to an allergen, the method comprising the step of administering to the respiratory tract of the subject an amount of a composition comprising a pharmaceutically acceptable carrier and live attenuated Bordetella pertussis sufficient to colonize the respiratory tract of the subject, wherein the colonization of the respiratory tract of the subject results in the reduction or the prevention of the development of airway inflammation in the subject compared to the level of airway inflammation in a corresponding subject not sensitized to the allergen and not administered with the composition, and wherein the live attenuated Bordetella pertussis are deficient in pertactin, tracheal cytotoxin (TCT), pertussis toxin (PTX), and dermonecrotic toxin (DNT).
Dependencies are inferred from the claim text.