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US 10,682,310 B2Granted
Therapeutic compounds and formulations for intranasal delivery
AssigneeRegents of the University of Minnesota
InventorsRonald A. Siegel, Mamta Kapoor, Narsihmulu Cheryala, Gunda I. Georg, James C. Cloyd
Life of this patent
Estimating the term…
Abstract
Certain embodiments of the invention provide a formulation suitable for nasal administration comprising water, a prodrug of a therapeutic agent, and an enzyme that is suitable for intranasal conversion of the prodrug to the therapeutic agent, as well as methods of use thereof.
Claims2
A formulation suitable for nasal administration comprising:
- water, a prodrug of a therapeutic agent, and an enzyme that is suitable for intranasal conversion of the prodrug to the therapeutic agent, wherein the therapeutic agent is midazolam or a precursor of midazolam, and wherein the enzyme is a human aminopeptidase.
Dependencies are inferred from the claim text.