Hydrogel microparticle scaffold with gradients of degradability and methods thereof
AssigneeWashington University
InventorsDonald L. Elbert, Jacob Roam
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Abstract
Disclosed herein is a device and method for regenerating tissue using a modular scaffold having a gradient of enzymatic degradability. The disclosure further relates to scaffolds made of microparticles comprising a cross-linked water-soluble polymer or cross-linked water-soluble polymers and a process for forming thereof.
Claims18
A modular scaffold comprising a plurality of hydrogel microparticles, wherein the hydrogel microparticles are crosslinked together with at least some crosslinks having tunable rates of enzymatic degradation, wherein the crosslinks with tunable degradation comprise a plasmin sensitive peptide sequence.
Dependencies are inferred from the claim text.