Clostridium acetobutylicum strains unable to produce hydrogen and useful for the continuous production of chemicals and fuels
AssigneesCentre National De La Recherche Scientifique, Institut National Des Sciences Appliquees, Institut National de Recherche Agronomique
InventorsPhilippe Soucaille, Ngoc-Phuong-Thao Nguyen, Benjamin Percheron, Christian Croux, Isabelle Meynial-Salles
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Abstract
The present invention relates to a new strain of Clostridium acetobutylicum modified to be unable to produce hydrogen and its use for the continuous production of bulk chemicals such as lactate, 1,3-propanediol, ethanol, butanol, isobutanol, 1,3-butanediol, acetate, acetone, isopropanol, 3-hydroxy-3-methylbutyrate and isobutene at high yield.
Claims23
A genetically modified Clostridium acetobutylicum unable to produce hydrogen, wherein the main [Fe—Fe]-hydrogenase encoding gene (hydA) and the main thiolase encoding gene (thlA) are attenuated to such an extent that the genetically modified Clostridium acetobutylicum is unable to produce hydrogen.
Dependencies are inferred from the claim text.