Process for producing an antibacterial coating composition for implants
AssigneeGebr. Brasseler GmbH & Co. KG
InventorsHenning Menzel, Marco Wassmann, Sebastian Stelljes, Meike Stiesch, Andreas Winkel
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Abstract
A process for producing an antibacterial coating composition for implants. The process includes the steps i) reaction of a monomer A which is based on (meth)acrylic acid and contains at least one epoxide with a polyguanidine by reaction of an amino group of the polyguanidine with the epoxide to give a (meth)acrylic acid-polyguanidine macromolecule and ii) polymerization of the (meth)acrylic acid-polyguanidine macromolecule with a monomer B which contains at least one polymerizable double bond and at least one phosphonate group by free-radical polymerization of the (meth)acrylic acid unit and the double bond.
Claims14
A process for producing an antibacterial coating composition for implants, which comprises the steps of:
- reaction of a monomer A which is based on (meth)acrylic acid and contains an epoxide with a polyguanidine by reaction of an amino group of the polyguanidine with the epoxide to give a (meth)acrylic acid-polyguanidine macro-molecule having a (meth)acrylic acid unit;
- and
- polymerization of the (meth)acrylic acid-polyguanidine macromolecule with a monomer B which contains a polymerizable double bond and at least one phosphonate group by free-radical polymerization of the (meth)acrylic acid unit and the polymerizable double bond;
- wherein the polyguanidine is prepared by reaction of guanidine hydrochloride with 1,2-bis(2-aminoethoxy)ethane and has at least one of the following formulae:
- where n is an integer in the range from 2 to 10.
A process for coating an implant with an antibacterial coating, which comprises the steps of:
- reaction of a monomer A which is based on (meth)acrylic acid and contains an epoxide with a polyguanidine by reaction of an amino group of the polyguanidine with the epoxide to give a (meth)acrylic acid-polyguanidine macromolecule having a (meth)acrylic acid unit,
- polymerization of the (meth)acrylic acid-polyguanidine macromolecule with a monomer B which contains a polymerizable double bond and at least one phosphonate group by free-radical polymerization of thea (meth)acrylic acid unit and the polymerizable double bond to produce a coating composition,
- dissolution of the coating composition in a solvent to form a solution of the coating composition,
- provision and degreasing of an implant,
- application of the solution of the coating composition to the implant and
- binding of the coating composition to the implant under action of temperatures in a range from 50 to 200° C.
Dependencies are inferred from the claim text.