HPV vaccines

A tri-segmented arenavirus viral vector comprising one L segment and two S segments, wherein a first S segment is engineered to carry an ORF encoding GP in a position under control of an arenavirus 3′ UTR and an ORF encoding a polypeptide comprising an amino acid sequence that is at least 99% identical to SEQ ID NO:

• 10 in a position under control of an arenavirus 5′ UTR and a second S segment is engineered to carry an ORF encoding NP in a position under control of an arenavirus 3′ UTR and an ORF encoding a polypeptide comprising an amino acid sequence that is at least 99% identical to SEQ ID NO:
• 10 in a position under control of an arenavirus 5′ UTR, wherein the arenavirus 3′ UTR is the 3′ UTR of the arenavirus S segment and the arenavirus 5′ UTR is the 5′ UTR of the arenavirus S segment.

A tri-segmented arenavirus viral vector comprising one L segment and two S segments, wherein a first S segment is engineered to carry an ORF encoding GP in a position under control of an arenavirus 5′ UTR and an ORF encoding a polypeptide comprising an amino acid sequence that is at least 99% identical to SEQ ID NO:

• 10 in a position under control of an arenavirus 3′ UTR and a second S segment is engineered to carry an ORF encoding NP in a position under control of an arenavirus 5′ UTR and an ORF encoding a polypeptide comprising an amino acid sequence that is at least 99% identical to SEQ ID NO:
• 10 in a position under control of an arenavirus 3′ UTR, wherein the arenavirus 3′ UTR is the 3′ UTR of the arenavirus S segment and the arenavirus 5′ UTR is the 5′ UTR of the arenavirus S segment.

A tri-segmented arenavirus viral vector comprising one L segment and two S segments, wherein a first S segment is engineered to carry an ORF encoding GP in a position under control of an arenavirus 3′ UTR and an ORF encoding a polypeptide consisting of an amino acid sequence that is 100% identical to SEQ ID NO:

• 10 in a position under control of an arenavirus 5′ UTR and a second S segment is engineered to carry an ORF encoding NP in a position under control of an arenavirus 3′ UTR and an ORF encoding a polypeptide consisting of an amino acid sequence that is 100% identical to SEQ ID NO:
• 10 in a position under control of an arenavirus 5′ UTR, wherein the arenavirus 3′ UTR is the 3′ UTR of the arenavirus S segment and the arenavirus 5′ UTR is the 5′ UTR of the arenavirus S segment, wherein the tri-segmented arenavirus viral vector is attenuated, and wherein the arenavirus viral vector is derived from LCMV.

A tri-segmented arenavirus viral vector comprising one L segment and two S segments, wherein a first S segment is engineered to carry an ORF encoding GP in a position under control of an arenavirus 3′ UTR and an ORF encoding a polypeptide consisting of an amino acid sequence that is 100% identical to SEQ ID NO:

• 10 in a position under control of an arenavirus 5′ UTR and a second S segment is engineered to carry an ORF encoding NP in a position under control of an arenavirus 3′ UTR and an ORF encoding a polypeptide consisting of an amino acid sequence that is 100% identical to SEQ ID NO:
• 10 in a position under control of an arenavirus 5′ UTR, wherein the arenavirus 3′ UTR is the 3′ UTR of the arenavirus S segment and the arenavirus 5′ UTR is the 5′ UTR of the arenavirus S segment, wherein the tri-segmented arenavirus viral vector is attenuated, and wherein the arenavirus viral vector is derived from Pichinde virus.