Antibacterial indigo naturalis or indigo-producing plant extract and use thereof
AssigneeGalderma S.A.
InventorsYin-Ku Lin, Philippe Andres, Laurent Chantalat
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Abstract
A pharmaceutical or cosmetic composition is provided. The composition includes an Indigo Naturalis or Indigo-producing plant extract, for inhibiting Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus. A method of inhibiting Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus, is also provided. The method includes contacting a cell with an effective amount of an Indigo Naturalis or Indigo-producing plant extract.
Claims17
A method of treating a skin disease comprising topically applying an effective amount an Indigo Naturalis extract to a subject in need thereof, wherein the Indigo Naturalis extract comprises relative to the total weight of the extract:
- 65% to 90% (w/w) indirubin,
- 0.1 to 15% (w/w) indigo;
- and
- 0.01 to 5% (w/w) trytanthrin, and
- wherein the skin disease is caused by one or more of the bacteria selected from the group consisting of Baccillus subtilis, Staphylococcus aureus, methicillin-reistant Staphylococcus aureus, Staphylococcus epidermis, Streptococcus pneumonia, Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa.
A method of inhibiting Staphylococcus aureus (S. aureus) comprising administering an effective amount of an Indigo Naturalis extract to a cell in need thereof, wherein the Indigo Naturalis extract comprises relative to the total weight of the extract:
- 65% to 90% (w/w) indirubin,
- 0.1 to 15% (w/w) indigo;
- and
- 0.01 to 5% (w/w) trytanthrin.
Dependencies are inferred from the claim text.