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US 10,662,239 B2Granted
Antibodies to amyloid beta
AssigneeMedImmune, LLC
InventorsMaria Groves, Suzanne Gustavsson, Kina Höglund, Chris Lloyd, Adrian Nickson, Camilla Niva, Sylvia Simon, David Lowne, Fraser Welsh, Per-Ola Freskgärd
Life of this patent
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Abstract
Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid beta 42 as therapeutic agents for binding amyloid beta 42 peptide and treating conditions associated with amyloidosis, such as Alzheimer's disease.
Claims12
An isolated antibody molecule that is selective for binding human amyloid beta 1-42 peptide (Aβ1-42) over human amyloid beta 1-40 peptide (Aβ1-40);
- wherein the antibody molecule comprises:
- (i) a VH domain comprising the following HCDRs:
- HCDR1 SEQ ID NO:
- 525,
- HCDR2 SEQ ID NO:
- 526, and
- HCDR3 SEQ ID NO:
- 527, and
- (ii) a VL domain comprising the following LCDRs:
- LCDR1 SEQ ID NO:
- 534,
- LCDR2 SEQ ID NO:
- 535, and
- LCDR3 SEQ ID NO:
- 536;
- and wherein the VL domain has a methinonine at the amino acid position corresponding to position 80 of SEQ ID NO:
- 533.
14 more elements
Dependencies are inferred from the claim text.