Compounds for treating parasitic infections

A method for inhibiting transport of heme across a membrane in a parasitic heme auxotrophic organism comprising contacting the parasitic organism with an effective amount of compound having the following structure:

• wherein R1 is selected from the group consisting of —OH, —OMe, and —NHR6, wherein R6 is selected from the group consisting of C1-C5 alkyl, C3-C6 cycloalkyl, substituted or unsubstituted pyridine, and phenyl;
• R2 is selected from the group consisting of —H, —F, —Cl, —OMe, and —OH;
• R3 is selected from the group consisting of C4-C6 cycloalkyl, phenyl, and substituted or unsubstituted pyridine;
• R4 is selected from the group consisting of substituted or unsubstituted C1-C8 alkyl, C4-C6 cycloalkyl, substituted or unsubstituted phenyl, substituted or unsubstituted alkyl amine, naphthyl, and heterocyclic;
• R5 is selected from the group consisting of
• R7 is selected from the group consisting of halogen, phenyl, and alkyl;
• n is 0-5;
• Y is selected from the group consisting of —H, —F, —Cl, and -Me;
• and
• Z is O, or NR8 wherein R8 is
• and R9 is selected from the group consisting of —OMe, and —F,
• such that the transport of the heme across the membrane is inhibited or prevented.