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US 10,661,276 B2Granted
Method for handling liquid using centrifugal force
AssigneeBiosurfit, S.A.
InventorsTania Moura Pires De Andrade Tenreiro, Luis Miguel Dias Martins, Fábio Miguel Rolo Pereira, Nuno Alexandre Esteves Reis
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Abstract
Devices and methods for handling liquids are provided. The devices and methods make use of centrifugal forces to drive liquid flow and facilitate one or more of the mixing, metering and sequencing of liquids, for example on a microfluidic device.
Claims3
A method of driving liquid flow in a device, the method comprising rotating the device at a first rotational frequency to transfer liquid from a first cavity of the device into a second cavity of the device, in communication with the first cavity;
- rotating the device at a second rotational frequency lower than the first rotational frequency to transfer liquid from the second cavity back into the first cavity and to transfer liquid from the first cavity into a downstream cavity in communication with the first cavity;
- and
- subsequent to transferring liquid from the first cavity into the downstream cavity, rotating the device at a fifth rotational frequency different to the second rotational frequency to control the volume of liquid which is transferred from the first cavity to the downstream cavity;
- wherein the fifth rotational frequency being greater than the second rotational frequency decreases the volume of liquid transferred;
- and
- wherein the fifth rotational frequency being less than the second rotational frequency increases the volume of liquid transferred.
3 more elements
Dependencies are inferred from the claim text.