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US 10,660,832 B2Granted
Acidic solid oral compositions without erosive potential in saliva and method for determining erosive potential in saliva
AssigneeIce Medico ehf
InventorsThorbjorg Jensdottir, Allan Bardow Jensen, Birgitte Nauntofte, Christian Buchwald
Life of this patent
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Abstract
Acidic oral compositions having calcium contents and effective pH-values in the area indicated by grey-tone in FIG. 2 are non-erosive in saliva and capable of stimulating saliva production, even in “dry mouth” patients. A new multi-step test method for determining erosive potential in saliva has been used for identifying the compositions.
Claims7
A method for determining dental erosive potential in saliva of an oral composition in a human mouth, comprising the steps of:
- (a) bringing the oral composition to be tested into contact with saliva in the mouth,
- (b) collecting a sample of the saliva under conditions so as to prevent CO2 from escaping from the sample,
- (c) measuring pH of the sample collected in step (b) to obtain a pH value,
- (d) removing CO2 from the sample collected in step (b),
- (e) adjusting pH of the sample from which CO2 has been removed in step (d) to the pH value measured in step (c), by adding a non-volatile acid or a non-volatile base, to obtain a pH-adjusted sample,
- (f) adding tooth substance to the pH-adjusted sample obtained from step (e), and observing any rise in pH of the pH-adjusted sample,
- (g) if a rise in pH is observed in the sample of step (f), titrating the sample to the pH value measured in (c) using an acid to determine an amount of the acid that is consumed, and
- (h) calculating an amount of tooth substance eroded based on the amount of acid consumed in step (g).
5 more elements
Dependencies are inferred from the claim text.