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AssigneeIntel Corporation
InventorsXing Su, Lei B. Sun, Jacque H. Georger, Jr.
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Apparatus and methods are disclosed for electrically active combinatorial-chemical (EACC) chips for biochemical analyte detection. An apparatus includes a substrate that has an array of regions defining multiple cells, wherein each of the cells includes a reaction cavity that contains multiple functional binding groups. A method of detecting an analyte providing the reaction cavity between a source and a drain or a pair of electrodes, applying a voltage and monitoring a parameter indicative of an analyte characteristic. A process of fabricating an EACC include bonding an analyte to the multiple functional binding groups of each reaction cavity, and forming an analyte sensing structure including the substrate.
An apparatus, comprising a substrate including an array of regions defining a plurality of cells, each of the plurality of cells including a reaction cavity containing multiple functional binding groups, wherein the array of regions comprises a first gradient of a first functional binding group and a second gradient of a second functional binding group, wherein an inter-molecular distance between the first functional binding group and the second functional binding group corresponds to a distance between binding locations on a biochemical analyte, wherein the plurality of cells comprise a chip for analyte detection having a feature size between 0.5 microns and 500 microns and analyte detection comprises creation of a binding site with one or more of the multiple functional binding groups, wherein the substrate comprises trichlorophenylsilane.
Dependencies are inferred from the claim text.