Turkey herpesvirus vectored recombinant containing avian influenza genes
AssigneeBiomune Company
InventorsMotoyuki Esaki, Lauren Elizabeth Jensen, Kristi M. Dorsey
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Abstract
The present invention provides a recombinant turkey herpesvirus modified by the presence of the cDNA encoding the hemagglutinin protein of avian influenza virus under a promoter. A poultry vaccine comprising the recombinant turkey herpesvirus described in the present invention can induce serological responses that may be easily detected by the hemagglutination inhibition assay but not by commercially available diagnostic ELISA kits; thus enabling easy differentiation between vaccination and field infection.
Claims4
A recombinant turkey herpesvirus comprising a hemagglutinin gene of an avian influenza virus and a cytomegalovirus immediate early promoter, wherein said hemagglutinin gene is under control of said cytomegalovirus immediate early promoter and wherein said hemagglutinin gene and said cytomegalovirus immediate early promoter are present between UL45 and UL46 of the turkey herpesvirus genome.
Dependencies are inferred from the claim text.