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US 10,654,928 B2Granted
Compositions and methods for immunotherapy
AssigneeMemorial Sloan Kettering Cancer Center
InventorsChristopher C. Kloss, Michel Sadelain
Life of this patent
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Abstract
The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen recognizing receptor and one of a chimeric costimulatory receptor. Methods of using the immunoresponsive cell include those for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.
Claims24
An immunoresponsive cell comprising:
- a) a chimeric antigen receptor (CAR) that binds to a first antigen with a dissociation constant (Kd) of about 5×10−8 M or more, wherein binding of the CAR to the first antigen is capable of delivering an activation signal to the immunoresponsive cell, and
- b) a chimeric co-stimulating receptor (CCR) that binds to a second antigen, wherein binding of the CCR to the second antigen is capable of delivering a costimulatory signal to the immunoresponsive cell but does not alone deliver an activation signal to the immunoresponsive cell,
- wherein the immunoresponsive cell is capable of (i) exhibiting negligible cytolytic activity against cells that are single positive for the first antigen, and (ii) inducing cytolytic activity against cells that are positive for both the first antigen and second antigens.
A kit comprising an immunoresponsive cell comprising:
- (a) a chimeric antigen receptor (CAR) that binds to a first antigen with a dissociation constant (Kd) of about 5×10−8 M or more, wherein binding of the CAR to the first antigen is capable of delivering an activation signal to the immunoresponsive cell, and
- (b) a chimeric co-stimulating receptor (CCR) that binds to a second antigen, wherein binding of the CCR to the second antigen is capable of delivering a costimulatory signal to the immunoresponsive cell but does not alone deliver an activation signal to the immunoresponsive cell,
- wherein the immunoresponsive cell is capable of (i) exhibiting negligible cytolytic activity against cells that are single positive for the first antigen, and (ii) inducing cytolytic activity against cells that are positive for both the first antigen and second antigens.
Dependencies are inferred from the claim text.