Compositions and methods for viral sensitization
AssigneesOttawa Hospital Research Institute, University of Ottawa
InventorsJean-Simon Diallo, Christopher Noyce Boddy, Mark Dornan, Ramya Krishnan, Rozanne Arulanandam, Fabrice Le Boeuf, Jeffrey Smith, Andrew Macklin
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Abstract
Provided are compounds of Formula (II) that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided. Compounds of Formula (II):
Claims13
A method for enhancing or increasing viral production in cells comprising administering a compound of Formula (II):
- or a pharmaceutically acceptable salt, or stereochemically isomeric form thereof, wherein:
- X1 is substituted N;
- X2 is halogen or NHX3, wherein X3 is a substituted or unsubstituted, linear or branched alkyl, alkenyl, or alkynyl;
- or substituted or unsubstituted aryl or heteroaryl;
- i is 0;
- - - - is absent when i is 0 such that X1 is directly bonded to the X4-bearing carbon through a single bond;
- and
- X4 is OH;
- to said cells prior to, after or concurrently with a virus, and culturing the virus and cells.
Dependencies are inferred from the claim text.