Propellane derivates and synthesis

A compound having the structure of Formula (I):

• wherein:
• R1 is —N3, —SCN, —NO, —C(═NOR2)(CN), —CH(═NOR2), CH(CO2H)(NHBoc), —CH(CO2H)(NH2), an optionally substituted cycloalkynyl, an optionally substituted heteroaryl(C1-6 alkyl), an optionally substituted heterocyclyl(C1-6 alkyl), an optionally substituted aminoalkyl or an optionally substituted haloalkoxy;
• and
• R2 is (C1 to C10) alkoxy, an optionally substituted C1-30 alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted cycloalkynyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl, an optionally substituted aryl(alkyl), an optionally substituted heteroaryl(alkyl), an optionally substituted heterocyclyl(alkyl), an optionally substituted aminoalkyl or an optionally substituted alkylamino;
• wherein an optionally substituted aminoalkyl is a NH2 group connected, as a substituent, via a lower alkylene group;
• and
• wherein the optionally substituted aminoalkyl is a straight-chained —CH2— tethering group, forming bonds to connect molecular fragments via its terminal carbon atoms and wherein the lower alkylene group can be substituted by replacing one or more hydrogen of the lower alkylene group or by substituting both hydrogens on the same carbon with a cycloalkyl group.