Compositions and methods for reducing organ rejection by reducing heparan sulfate in donor transplants
AssigneeUniversity of Florida Research Foundation, Inc.
InventorAlexandra Rose Lucas
Life of this patent
Estimating the term…
Abstract
Disclosed here are polypeptides, derived from the Myxomavirus-derived secreted glycoprotein, M-T7, comprising point mutations that interfere with chemokine-glycosaminoglycan binding. Compositions containing such M-T7 derived polypeptides with point mutations are therefore useful in preventing, blocking and/or reducing rejection of a transplant.
Claims11
A method of treating or reducing rejection of a transplant, the method comprising contacting an organ with a therapeutically effective amount of a polypeptide comprising the sequence set forth in SEQ ID NO:
- 2 or 3.
A method of modulating T cell receptor (TCR) expression in vitro or in vivo, the method comprising:
- contacting a cell in vitro, or contacting an organ prior to transplantation, with a therapeutically effective amount of a polypeptide comprising the sequence set forth in SEQ ID NO:
- 2 or 3.
A method of treating a kidney prior to transplantation, the method comprising contacting the kidney with a polypeptide comprising the sequence set forth in SEQ ID NO:
- 2 or 3.
Dependencies are inferred from the claim text.