Thromboresistant coatings for aneurysm treatment devices
AssigneeIncept, LLC
InventorsYi Yang, Tiffany C. Suekama, Syed Hossainy, Viet Ton, Farhad Khosravi, Alex Jared Rowson, Benjamin Robert Palone, Henry Lao
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Abstract
Disclosed are coating compositions, processes, and designs for endowing vascular devices with thromboresistant and endothelializing properties. Also disclosed are designs of vascular devices used as aneurysm treating devices for assisting in the delivery, packing, and maintenance of embolization coils within an aneurysm, particularly a neurovascular aneurysm.
Claims55
A device for insertion into a blood vessel lumen for treatment of an aneurysm, comprising:
- a generally cylindrical section comprising a plurality of struts forming interstitial gaps between the struts, the generally cylindrical section having a proximal face and a distal face and defining a device lumen extending along an axial direction from the proximal face to the distal face, the lumen being configured to allow blood flow through the device, the generally cylindrical section being configured to provide a radially outward counter force to compression adjacent the proximal face which is greater than a radially outward counter force to compression near a middle of the generally cylindrical section;
- and
- a proximal tapered section comprising a plurality of struts extending from a circumference of the proximal face to a proximal apex,
- wherein the proximal apex is radially aligned with the circumference of the proximal face or positioned radially outside the circumference of the proximal face, and
- wherein the plurality of struts of the proximal tapered section extend from different points on the circumference of the proximal face in an axial and circumferential direction to the proximal apex, such that none of the plurality of struts cross through a cross-sectional area defined by the device lumen.
A device for insertion into a blood vessel lumen for treatment of an aneurysm, comprising:
- a generally cylindrical section comprising a plurality of struts forming interstitial gaps between the struts, the generally cylindrical section having a proximal face and a distal face and defining a device lumen extending along an axial direction from the proximal face to the distal face, the lumen being configured to allow blood flow through the device;
- and
- a proximal tapered section comprising a plurality of struts extending from a circumference of the proximal face to a proximal apex,
- wherein the proximal apex is radially aligned with the circumference of the proximal face or positioned radially outside the circumference of the proximal face, and
- wherein the plurality of struts of the proximal tapered section extend from different points on the circumference of the proximal face in an axial and circumferential direction to the proximal apex, such that none of the plurality of struts cross through a cross-sectional area defined by the device lumen,
- wherein the plurality of struts of the generally cylindrical section are coated with a coating forming a gradient in at least one biological property along a length of the device in a direction aligned with the device lumen,
- wherein the at least one biological property comprises reduction of thrombus formation and promotion of endothelialization, and
- wherein the reduction of thrombus formation increases as promotion of endothelialization decreases.
Dependencies are inferred from the claim text.