Back to results
US 10,650,519 B2Granted
Voxel-based methods for assessing subjects using magnetic resonance imaging
AssigneeThe Trustees of Columbia University in the City of New York
InventorsRamin Parsey, Arthur Mikhno
Life of this patent
Estimating the term…
Abstract
The subject matter disclosed herein relates to methods for diagnosing a neurological disorder in a subject. In certain aspects, the methods described herein involve determining one or more critical areas in the brain from PET data where two groups differ and measuring PET signal within determined critical areas in a new subject in order to assign risk or diagnosis.
Claims48
A computer-implemented method for diagnosing or determining risk of Alzheimer's disease in a subject, the method comprising:
- (a) determining the presence of a radioactive signal from an administered radioligand in at least one individual in a control group and at least one individual in a reference group to generate primary brain scan image voxel data of radioligand distribution in a brain of at least one individual in the control group and at least one individual in the reference group, wherein the primary brain scan image is generated using Positron Emission Tomography (PET),
- (b) generating secondary brain scan image data for the individuals in the control and reference groups, wherein the secondary scan brain image data is generated using a different type of brain scan than the primary brain scan image data,
- (c) generating a probability-corrected time-activity curve data for each voxel in the primary brain scan image of the at least one individual in the control and reference group,
- (d) processing the probability-corrected time-activity curve data of the at least one individual in the control and reference group to generate a voxel binding outcome map data of the at least one individual in the control and reference group,
- (e) transforming the voxel binding outcome map data of the at least one individual in the control and reference group into a normalized space to generate a normalized voxel binding outcome map data of the at least one individual in the control and reference group
- (f) processing the normalized voxel binding outcome map data of the at least one individual in the control and reference group using statistical analysis to identify one or more voxels of interest (VOI) in the normalized voxel binding outcome map data to generate a VOI map data for differentiating of the at least one individual in the control and reference group, and
- (g) applying the VOI map data to the voxel binding outcome map data of the test subject to generate a mean cortical binding value to diagnose or determine risk of Alzheimer's disease in the subject wherein the voxel binding outcome map data of said test subject is generated from Magnetic Resonance Imaging (MRI) using a MRI scanner.
4 more elements
Dependencies are inferred from the claim text.