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US 10,649,669 B2Granted
Processes for making opioids including 14-hydroxycodeinone and 14-hydroxymorphinone
AssigneeJohson Matthey Public Limited Company
InventorsSaroop Matharu, Brian Heinrich, Ewart Grant, Hongzhi Zhang
Life of this patent
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Abstract
Improved processes for making opioid products having low impurity levels including making 14-hydroxycodeinone and 14-hydroxymorphinone from thebaine and oripavine, respectively.
Claims32
A method of making an oxymorphone free base comprising the steps of:
- a. oxidizing oripavine with a peroxyacid to form 14-hydroxymorphinone;
- b. adding an alcohol to the reaction mixture at or about upon completion of step a;
- c. treating the reaction mixture of step b with a mixture of ammonium hydroxide solution and water to yield 14-hydroxymorphinone;
- and
- d. converting the 14-hydroxymorphinone to the oxymorphone free base.
2 more elements
A method of making an oxycodone free base comprising the steps of:
- a. oxidizing thebaine with a peroxyacid to form 14-hydroxycodeinone;
- b. adding an alcohol to the reaction mixture at or about upon completion of step a;
- c. treating the reaction mixture of step b with a mixture of ammonium hydroxide solution and water to yield 14-hydroxycodeinone;
- and
- d. converting the 14-hydroxycodeinone to the oxycodone free base.
2 more elements
Dependencies are inferred from the claim text.