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US 10,649,187 B2Granted
Dosimeters including lensless imaging systems
AssigneeAlentic Microscience Inc.
InventorAlan Marc Fine
Life of this patent
Estimating the term…
Abstract
Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject. The method also comprises automatically differentiating cells of different types in the image, generating a count of one or more cell types based on the automatic differentiation, and deriving a radiation dose the subject has absorbed based on the count.
Claims20
An apparatus comprising:
- a portable, battery-powered, pocket-sized bio-dosimeter comprising components including at least the following:
- an imaging sensor having an array of light-sensitive elements exposed at a surface of the imaging sensor,
- a second surface movable toward the surface of the imaging sensor to form a monolayer of a blood sample of a subject on the surface of the imaging sensor,
- optical paths for light to pass through the monolayer of the blood sample and reach the surface of the imaging sensor,
- a user interface configured to receive control inputs from a user of the bio-dosimeter and to provide information to the user,
- a processor, and
- a memory storing instructions executable by the processor to interact with the user interface, and configured to determine a count per volume of lymphocytes in the blood sample based on the light reaching the surface of the imaging sensor, and provide the count for use in determining whether the subject needs medical care for radiation exposure and reporting the determination to the subject or the user or both, one or more of the components of the bio-dosimeter being disposable or reusable.
4 more elements
Dependencies are inferred from the claim text.