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US 10,648,976 B2Granted
Sensor integration in lateral flow immunoassays and its applications
AssigneeRobert Bosch GmbH
InventorsSam Kavusi, Frederik Kotz
Life of this patent
Estimating the term…
Abstract
Lateral flow immunoassay devices for determining the concentration of an analyte in a sample and methods for measuring analyte concentration in sample using such lateral flow immunoassay devices.
Claims20
A lateral flow immunoassay device for measuring an analyte having a solid support including absorbent material for providing capillary flow comprising:
- a) a sample portion for receiving a sample;
- b) a conjugate portion comprising conjugate particulate material;
- c) a diagnostic portion comprising a binder for the analyte;
- d) an absorbent portion of absorbent material for providing capillary flow;
- and
- e) at least one electrical sensor;
- wherein:
- the sample portion, conjugate portion, diagnostic portion, and absorbent portion are in capillary flow communication, whereby the sample flows across the binder in the diagnostic portion to provide contact between the sample and the binder;
- the at least one electrical sensor and the binder are both placed on one side of the solid support;
- the at least one electrical sensor comprises at least one electrode pair;
- and
- at least one of the following:
- the at least one electrode pair is an electrode pair integrated on at least one of the sample portion and absorbent portion;
- the at least one electrical sensor comprises two electrode pairs to determine the flow rate of the sample across the diagnostic portion of the lateral flow immunoassay device;
- and
- the at least one electrical sensor comprises a series of multiple electrode pairs arranged side-by-side across the flow path of the sample to determine the flow shape of the sample across the diagnostic portion of the lateral flow device.
13 more elements
A lateral flow immunoassay device for measuring an analyte having a solid support including absorbent material for providing capillary flow comprising:
- a) a sample portion for receiving a sample;
- b) a conjugate portion comprising conjugate particulate material;
- c) a diagnostic portion comprising a binder for the analyte;
- d) an absorbent portion of absorbent material for providing capillary flow;
- and
- e) at least one electrical sensor;
- wherein:
- the sample portion, conjugate portion, diagnostic portion, and absorbent portion are in capillary flow communication, whereby the sample flows across the binder in the diagnostic portion to provide contact between the sample and the binder;
- the at least one electrical sensor and the binder are both placed on one side of the solid support;
- and
- at least one of the following:
- the at least one electrical sensor is connected to a processing unit and at least one of:
- the processing unit is configured to compute a plurality of parameters of the sample;
- the processing unit is configured to compute one or more parameters of the sample, and at least one of:
- the one or more parameters of the sample include at least one of a flow rate of the sample across the diagnostic portion, a flow shape of the sample across the diagnostic portion, a temperature of the sample at the diagnostic portion, and a pH of the sample at the diagnostic portion;
- and
- the processing unit is connected to the lateral flow immunoassay device externally;
- the at least one electrical sensor comprises a defined structure of conductive material with resistances in a defined range for determining the temperature of the sample flowing across the diagnostic portion of the lateral flow device;
- and
- the at least one electrical sensor comprises at least one temperature sensor, and the device further comprises a heating element located, in the flow direction of the sample, before the at least one temperature sensor.
17 more elements
Dependencies are inferred from the claim text.