Method and device for quality controlling a blood-based product

A method for quality controlling a blood-based product, wherein the method comprises:

• providing a computer comprising one or a plurality of processors or controllers;
• storing, in a database in a memory of the computer, a plurality of reference spectra, wherein the stored plurality of reference spectra includes one or more of:
• a position of Raman peaks and/or wavenumber ranges of fresh cells of different cell types of blood based products, wherein the blood-based products comprise one or more of an erythrocyte concentrate, a thrombocyte concentrate, a granulocyte concentrate, a leukocyte concentrate, whole blood and blood plasma;
• a position of Raman peaks and/or wavenumber ranges of functionally modified cells of the different cell types of the blood based products and
• information regarding ranges of multi-dimensional spaces of a cluster analysis, in which the reference spectra are respectively arranged;
• collecting, in an optical trap, at least one cell of a sample of a liquid blood-based product from one of the plurality of blood donors
• recording a Raman spectrum of the at least one cell of the sample by means of Raman spectroscopy;
• comparing the recorded Raman spectrum of the at least one cell of the sample with the plurality of reference spectra stored in the database;
• evaluating one or more of cell age, cell death, sterility, levels of impurity and cell functionality of the at least one cell of the sample based on results of the comparison;
• and
• determining whether the liquid blood-based product donated by the one of the plurality of blood donors is usable for a transfusion based on results of the evaluation.