Online chemical derivatization using a cooled programmed temperature vaporization inlet
AssigneeThe Government of the United States of America, as represented by the Secretary of the Navy
InventorsLauryn E. DeGreeff, Christopher J. Katilie
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Abstract
A method of detecting an analyte by: providing a derivatizing agent that is reactive with the analyte; delivering the derivatizing agent into a chamber; delivering a sample of a gas suspected of containing the analyte into the chamber before or after delivering the derivatizing agent, while the chamber is maintained at a temperature that retains the derivatizing agent and any analyte and that allows reaction between the derivatizing agent and any analyte in the chamber to form a derivatized analyte; warming the chamber to cause evaporation of any derivatized analyte; and delivering the derivatized analyte in the chamber into a gas chromatograph column.
Claims19
A method of detecting an analyte comprising:
- providing a derivatizing agent that is reactive with the analyte;
- delivering the derivatizing agent into a chamber;
- delivering a sample of a gas suspected of containing the analyte into the chamber before or after delivering the derivatizing agent;
- wherein the chamber is maintained at a temperature that retains the derivatizing agent and any analyte and that allows reaction between the derivatizing agent and any analyte in the chamber to form a derivatized analyte;
- warming the chamber to cause evaporation of any derivatized analyte;
- and
- delivering the evaporated derivatized analyte into a gas chromatograph column;
- wherein delivering the derivatizing agent, delivering the sample, and delivering the derivatized analyte are performed using a six-way valve.
A method of detecting an analyte comprising:
- delivering an internal standard into a chamber;
- delivering a sample of a gas suspected of containing the analyte into the chamber before or after delivering the internal standard;
- wherein the chamber is maintained at a temperature that retains the internal standard and any analyte;
- warming the chamber to cause evaporation of the internal standard and any analyte;
- and
- delivering the evaporated internal standard and analyte into a gas chromatograph column;
- wherein delivering the internal standard, delivering the sample, and delivering into the gas chromatograph are performed using a six-way valve.
A method of detecting ammonium comprising:
- providing a derivatizing agent that is reactive with ammonium;
- delivering the derivatizing agent into a chamber;
- delivering a sample of a gas suspected of containing ammonium into the chamber before or after delivering the derivatizing agent;
- wherein the chamber is maintained at a temperature that retains the derivatizing agent and any ammonium and that allows reaction between the derivatizing agent and any ammonium in the chamber to form a derivatized analyte;
- warming the chamber to cause evaporation of any derivatized analyte;
- and
- delivering the evaporated derivatized analyte into a gas chromatograph column.
A method of detecting an analyte comprising:
- providing butyl chloroformate;
- delivering the butyl chloroformate into a chamber;
- delivering a sample of a gas suspected of containing the analyte into the chamber before or after delivering the butyl chloroformate;
- wherein the chamber is maintained at a temperature that retains the butyl chloroformate and any analyte and that allows reaction between the butyl chloroformate and any analyte in the chamber to form a derivatized analyte;
- warming the chamber to cause evaporation of any derivatized analyte;
- and
- delivering the evaporated derivatized analyte into a gas chromatograph column.
Dependencies are inferred from the claim text.