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US 10,648,045 B2Granted
Chimeric polypeptides
AssigneeIpsen Biopharm Ltd.
InventorsDaniel Kwan, David Burgin, Stephen Gavin Hackett
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Abstract
Chimeric clostridial neurotoxins in which the activation loop has been replaced by an activation loop from a different subtype within the same serotype. Methods of producing, activating, and using such neurotoxins. Compositions comprising such neurotoxins. Polynucleotides, vectors and cells for expressing such neurotoxins.
Claims12
A chimeric polypeptide comprising:
- (a) an LHN backbone from a BoNT/F2 subtype;
- and
- (b) an activation loop region from a BoNT/F1 subtype;
- wherein the LHN backbone comprises both:
- (i) a light chain domain of the BoNT/F7 subtype;
- and
- (ii) a HN domain of the BoNT/F7 subtype.
4 more elements
Dependencies are inferred from the claim text.