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US 10,648,035 B2Granted
Methods and compositions for diagnosing and treating gastric cancer
AssigneeThe Johns Hopkins University
InventorsRachana Agarwal, Stephen J. Meltzer
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AssigneeThe Johns Hopkins University
InventorsRachana Agarwal, Stephen J. Meltzer
Estimating the term…
The present invention relates to the field of gastric cancer. More specifically, the present invention provides methods and compositions for diagnosing and treating gastric cancer. In a specific embodiment, a method for diagnosing gastric cancer or a likelihood thereof in a patient comprises the steps of (a) providing a sample from the patient; (b) measuring the methylation levels of one or more biomarkers in the sample collected from the patient; and (c) predicting gastric cancer in the patient if the biomarkers are hypermethylated. In a more specific embodiment, the one or more biomarkers comprises tight junction protein claudin-1 1 (CLD-N11), the transcription factor BarH-like homeobox (BARX1), basonuclin1 (BNC1), Coagulation factor C homolog (COCH), filamin C gamma (FLNC), cytoglobin B (CYGB), glutamine-fructose-6-phospahe-transaminase-2 (GFPT2), heat-shock-70 kDa protein-6 (HSPA6), snail homolog 1 (SNAL1), skin calmodulin-related factor (SCARF), and tumor protein p53 binding protein 2 (TP53BP2).
A method comprising the steps of (a) measuring the methylation levels of the promoter region of a panel of genes in a sample collected from a patient, wherein the panel comprises BarH-like homeobox (BARX1), cytoglobin B (CYGB), claudin-11 (CLDN11) and snail homolog 1 (SNAL1);
A method comprising the steps of:
A method comprising the steps of:
Dependencies are inferred from the claim text.