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US 10,648,034 B2Granted
Compositions and methods for diagnosing and treating meningioma
AssigneeYale University
InventorMurat Gunel
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Abstract
The present invention relates to mutations associated with neoplasia, such as meningioma. Thus, the invention relates to compositions and methods useful for the assessment, characterization, classification and treatment of neoplasia, including meningioma, based upon the presence or absence of mutations that are associated with neoplasia, including meningioma.
Claims3
A method comprising:
- a) obtaining a biological sample from a subject;
- b) detecting at least one KLF4 K409Q mutation in the sample by performing an assay on the biological sample selected from the group consisting of PCR, Northern blotting, Southern blotting, DNA array analysis, and direct sequence analysis, thereby identifying the subject as having a meningioma;
- and
- c) administering a meningioma treatment to the subject, wherein the treatment is at least one selected from the group consisting of surgery and radiation.
1 more element
Dependencies are inferred from the claim text.