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US 10,648,033 B2Granted
Biomarkers for use in prognosis of mortality in critically ill patients
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsPurvesh Khatri, Timothy E. Sweeney
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Abstract
Biomarkers and methods of using them for aiding diagnosis, prognosis, and treatment of critically ill patients are disclosed. In particular, the invention relates to the use of biomarkers for prognosis of mortality in critically ill patients with sepsis, severe trauma, or burns.
Claims11
A method of administering urgent care to a patient, comprising:
- (a) identifying the patient as having a high risk of mortality within 30 days, wherein the patient has increased levels of expression of the DEFA4, CD163, PER1, RGS1, HIF1A, SEPP1, C11orf74, and CIT biomarkers and decreased levels of expression of the LY86, TST, and KCNJ2 biomarkers compared to reference value ranges;
- and
- (b) administering an antimicrobial therapy to the patient, administering an immunomodulating therapy to the patient, or administering an organ-specific treatment to the patient.
Dependencies are inferred from the claim text.