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US 10,647,999 B2Granted
Promoter
AssigneeOxford Genetics Limited
InventorsRyan Cawood, Richard Parker-Manuel, Weiheng Su
Life of this patent
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Abstract
The present invention relates to nucleic acid molecules which are capable of promoting transcription of operably-linked heterologous polynucleotides in mammalian cells. The invention also relates to expression vectors and host cells which comprise the nucleic acid molecules of the invention. Such expression vectors may be used to produce recombinant proteins, e.g. antibodies and lentiviral polypeptides.
Claims15
A nucleic acid molecule comprising:
- (a) a first polynucleotide having at least 80% nucleotide sequence identity to the nucleotide sequence set forth in SEQ ID NO:
- 1 or SEQ ID NO:
- 2;
- and
- (b) a second polynucleotide having at least 80% nucleotide sequence identity to the nucleotide sequence set forth in SEQ ID NO:
- 4;
- wherein the first polynucleotide and the second polynucleotide are joined 5′-3′ either contiguously or wherein 1-10 linker nucleotides are present between the first and second polynucleotides, and wherein said nucleic acid molecule is capable of promoting transcription of an operably-linked heterologous polynucleotide in a mammalian cell.
4 more elements
Dependencies are inferred from the claim text.