US 10,647,994 B2Granted

Ras opposite (ROP) and related nucleic acid molecules that confer resistance to coleopteran and/or hemipteran pests

AssigneeDow AgroSciences LLC

InventorsKenneth E. Narva, Huarong Li, Chaoxian Geng, Kanika Arora, Balaji Veeramani, Premchand Gandra, Sarah Worden, Andreas Vilcinskas, Eileen Knorr, Elane Fishilevich, Murugesan Rangasamy, Meghan Frey

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Abstract

This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran and/or hemipteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran and/or hemipteran pests. The disclosure also concerns methods for making that express nucleic acid molecules useful for the control of coleopteran and/or hemipteran pests, and the plant cells and plants obtained thereby.

Claims25

Dependent claims

A double-stranded ribonucleic acid (dsRNA) molecule comprising a first polyribonucleotide consisting of at least 23 contiguous nucleotides of the polyribonucleotide encoded by a polynucleotide selected from the group consisting of SEQ ID NO:1, SEQ ID NO:115, SEQ ID NO:120, SEQ NO:122, SEQ ID NO:124, SEQ ID NO:126, SEQ ID NO:131, and SEQ ID NO:133,

wherein the first polyribonucleotide is hybridized in the dsRNA molecule to a second polyribonucleotide that is the complement or reverse complement of the first polyribonucleotide, and
wherein delivery of the dsRNA molecule inhibits the expression of a target gene in a coleopteran or hemipteran insect selected from the group consisting of Diabrotica virgifera, Euschistus heros, and Meligethes aeneus.

Dependencies are inferred from the claim text.

Facts

Application: 14/577,811Filed 19 Dec 2014 · us provisional application
Priority: 20 Dec 2013
Published: US 2015/0176025 A125 Jun 2015
Granted: 12 May 2020
Term ends: Not estimatedThe source records don’t support an estimate.

Classification8 codes

C12N 15/8286
For biotic stress resistance, pathogen resistance, disease resistance: for insect resistance
C12N 15/113
DNA or RNA fragments; Modified forms thereof ; Non-coding nucleic acids having a biological activity: non-coding nucleic acids modulating the…
C12N 15/8218
Methods for controlling, regulating or enhancing expression of transgenes in plant cells: antisense, co-suppression, viral induced gene silencing…
C12N 2310/14
Type of nucleic acid: interfering nucleic acids [NA]