Approach for treating inflammatory disorders
AssigneeSecama Pharmaceuticals GmbH & Co KG
InventorsFrank Jaschinski, Ksenija Schirduan, Sven Michel
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Abstract
The present invention relates to a novel approach for treating inflammatory disorders and other diseases, which is based on targeting ROR gamma t mRNA. The invention is directed to oligonucleotides comprising 10 to 22 modified or unmodified nucleotides complementary to specifically selected regions of the RORC, transcript variant 2 mRNA (RORC2), which codes for the ROR gamma t protein.
Claims12
An oligonucleotide consisting of from 15 to 21 nucleotides, comprising the nucleic acid sequence of SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 6, SEQ ID NO. 7, SEQ ID NO. 8, SEQ ID. NO. 9, SEQ ID NO. 10, SEQ ID NO. 11, SEQ ID NO. 23, SEQ ID NO. 24, SEQ ID NO. 25, SEQ ID NO. 26, SEQ ID NO. 53, SEQ ID NO. 54, SEQ ID NO. 55, SEQ ID NO. 56, SEQ ID NO. 57, SEQ ID NO. 58, SEQ ID NO. 59, SEQ ID NO. 60, SEQ ID NO. 61, or SEQ ID NO. 62, wherein the oligonucleotide is modified.
Dependencies are inferred from the claim text.