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US 10,647,964 B2Granted
Non-neuroinvasive viruses and uses thereof
AssigneesNorthwestern University, Board of Regents of the University of Nebraska, Trustees of Tufts College
InventorsGregory A. Smith, Patricia Jane Sollars, Gary Edward Pickard, Ekaterina E. Heldwein
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Abstract
Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
Claims16
A variant herpesvirus or alphaherpes virus particle comprising at least two mutations in a UL37 protein selected from the group consisting if SEQ ID NO:
- 34, SEQ ID NO:
- 35, a sequence having at least 90% sequence identity to SEQ ID NO:
- 34 and a sequence having at least 90% sequence identity to SEQ ID NO:
- 35, wherein the mutations are at a position selected from the group consisting of Q403, E452, Q455, Q511, and R515, wherein said virus particle exhibits reduced neuro-invasiveness relative to a virus particle lacking said mutation, and wherein the ability of the virus to replicate in peripheral tissues is retained.
1 more element
Dependencies are inferred from the claim text.