Bioactive aluminoborate glasses
AssigneeCorning Incorporated
InventorsHuayun Deng, Ye Fang, Qiang Fu, John Christopher Mauro
Life of this patent
Estimating the term…
Abstract
An aluminoborate glass composition, including B2O3, Al2O3, P2O5, Na2O, and CaO, as defined herein. Also disclosed are bioactive compositions including the disclosed aluminoborate glass composition, a suitable fluid, and at least one live cell. Also disclosed is method of limiting the amount of boron released into an aqueous solution from a disclosed aluminoborate-containing glass composition as defined herein. Also disclosed is a method of proliferating cells on a bioactive substrate as defined herein.
Claims16
A bioactive composition, comprising:
- an aluminoborate glass composition, consisting of:
- 30 to 60 mol % B2O3,
- 8 to 30 mol % Al2O3,
- 1 to 5 mol % P2O5,
- 3 to 30 mol % Na2O,
- 10 to 30 mol % CaO, and
- balance of at least one alkali or alkaline earth metal oxide, based on a 100 mol % total of the composition;
- and
- at least one live cell.
A method of controlling the rate of boron released into an aqueous solution from an aluminoborate-containing glass composition, comprising:
- contacting the aluminoborate-containing glass composition with an aqueous solution;
- wherein the aluminoborate-containing glass composition comprises sources of:
- 30 to 60 mol % B2O3,
- 8 to 30 mol % Al2O3,
- 1 to 5 mol % P2O5,
- 3 to 30 mol % Na2O,
- 10 to 30 mol % CaO, and
- balance of at least one alkali or alkaline earth metal oxide, based on a 100 mol % total of the composition,
- wherein the amount of Al2O3 controls the amount of boron released into the aqueous solution or the boron release kinetics of the composition.
Dependencies are inferred from the claim text.