Electrochemical sensor system
AssigneeAscensia Diabetes Care Holdings AG
InventorsPaul Valint, Doug H. Williamson, Boru Zhu
Life of this patent
Estimating the term…
Abstract
An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1.
Claims17
An electrochemical sensor system comprising:
- an electrochemical sensor having at least a counter electrode and a working electrode;
- and
- a hydrogel composition contacting the working electrode, the hydrogel composition comprising a first monomer, a second monomer, a cross-linking agent, and a solvent, the first monomer being selected from Formula I, wherein Formula I is
- wherein the combination of R and R1 is selected from 1 carbon to 5 carbon atoms such that a 3-7 member heterocyclic moiety is formed;
- the second monomer being selected from the group consisting of Formula III, wherein Formula III is
- wherein
- R5 is selected from (C3-C18)alkyl, wherein the alkyl is optionally substituted with one or more substituents selected from halos, haloalkyls, cycloalkyls, nitros, cyanos, 4-8 member heterocyclic moieties, wherein the heterocyclic moieties are optionally substituted with one or more alkyls, halos, haloalkyls, cycloalkyls, nitros, and cyanos,
- wherein the ratio of the first monomer to the second monomer is from about 20:80 to about 80:20.
An electrochemical sensor system comprising:
- an electrochemical sensor having at least a counter electrode and a working electrode;
- and
- a hydrogel composition contacting the working electrode, the hydrogel composition comprising a first monomer, a second monomer, a cross-linking agent, and a solvent, the first monomer being selected from Formula I, wherein Formula I is
- wherein the combination of R and R1 is selected from 1 carbon to 5 carbon atoms such that a 3-7 member heterocyclic moiety is formed, the first monomer being N-vinyl pyrrolidone or N-vinyl caprolactam;
- the second monomer being selected from the group consisting of Formula III, wherein Formula III is
- wherein
- R5 is selected from (C3-C18)alkyl, wherein the alkyl is optionally substituted with one or more substituents selected from halos, haloalkyls, cycloalkyls, nitros, cyanos, 4-8 member heterocyclic moieties, wherein the heterocyclic moieties are optionally substituted with one or more alkyls, halos, haloalkyls, cycloalkyls, nitros, and cyanos,
- wherein the ratio of the first monomer to the second monomer is from about 20:80 to about 80:20.
A method of determining an analyte concentration, the method comprising the acts of:
- placing a hydrogel composition on skin, the hydrogel composition comprising a first monomer, a second monomer, a cross-linking agent, and a solvent, the first monomer being selected from Formula I, wherein Formula I is
- wherein the combination of R and R1 is selected from 1 carbon to 5 carbon atoms such that a 3-7 member heterocyclic moiety is formed;
- the second monomer being selected from the group consisting of Formula III, wherein Formula III is
- wherein
- R5 is selected from (C3-C18)alkyl, wherein the alkyl is optionally substituted with one or more substituents selected from halos, haloalkyls, cycloalkyls, nitros, cyanos, 4-8 member heterocyclic moieties, wherein the heterocyclic moieties are optionally substituted with one or more alkyls, halos, haloalkyls, cycloalkyls, nitros, and cyanos, and
- wherein the ratio of the first monomer to the second monomer is from about 20:80 to about 80:20;
- providing a sensor, the hydrogel composition located generally between and coupling the skin and the sensor;
- and
- sampling of the interstitial fluid to determine the analyte concentration using the sensor.
Dependencies are inferred from the claim text.