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US 10,647,778 B2Granted
Bi-specific chimeric antigen receptor and uses thereof
AssigneeUniversity of Florida Research Foundation, Inc.
InventorLung-Ji Chang
Life of this patent
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Abstract
Provided herein are bi-specific chimeric antigen receptors (CARs), such as those specific for CD138 and BCMA. Use of the CARs in immune cells (e.g., T cells), compositions, and methods are also contemplated.
Claims19
A chimeric antigen receptor (CAR) comprising:
- (i) a first single chain Fv (scFv) specific for CD138 comprising the amino acid sequence set forth in SEQ ID NO:
- 36;
- and
- (ii) a second single chain Fv (scFv) specific for BCMA comprising the amino acid sequence set forth in SEQ ID NO:
- 38.
2 more elements
Dependencies are inferred from the claim text.