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US 10,647,774 B2Granted
Anti-DR5 family antibodies, bispecific or multivalent anti-DR5 family antibodies and methods of use thereof
AssigneeGenmab B.V.
InventorsClaudine Brigitte Fernande Vermot-Desroches, Olivier Frédéric Subiger, Laurence Françoise Jeanne-Marie Bourdin
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Abstract
Anti-DR5 family member antibodies and bispecific antibodies comprising one or more anti-DR5 family member antibodies are disclosed. These antibodies can be used to trigger cell death on DR5 positive cells.
Claims9
An isolated nucleic acid encoding a variable light (VL) region or a variable heavy (VH) region of an antibody capable of binding a DR5 receptor, wherein the isolated nucleic acid encoding the VL region comprises a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 1, 5, 36, and 40, and the isolated nucleic acid encoding the VH region comprises a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 3, 7, 34, and 38.
Dependencies are inferred from the claim text.