Anti-GM-CSF antibodies and uses thereof
AssigneeI-Mab Biopharma Co., Ltd.
InventorsZhengyi Wang, Lei Fang, Bingshi Guo, Jingwu Zang
Life of this patent
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Abstract
Provided are anti-GM-CSF antibodies or fragments thereof including humanized antibodies and fragments. Also provided are uses of the antibodies and fragments for therapeutic, diagnostic and prognostic purposes. Therapeutic uses of the antibodies and fragments, for example include the treatment of inflammatory and autoimmune diseases and disorders.
Claims22
An isolated antibody or antigen-binding fragment thereof, wherein the antibody or fragment thereof has specificity to a human granulocyte macrophage colony-stimulating factor (GM-CSF) protein and comprises a heavy chain variable region (VH) complementarity determining region (CDR) 1 (CDR1) of SEQ ID NO:
- 1, a VH CDR2 of SEQ ID NO:
- 2, a VH CDR3 of SEQ ID NO:
- 3, a light chain variable region (VL) CDR1 of SEQ ID NO:
- 4, a VL CDR2 of SEQ ID NO:
- 5, and a VL CDR3 of SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.