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US 10,647,761 B2Granted
Anti-alpha-synuclein antibodies and methods of use
AssigneeHoffmann-La Roche Inc.
InventorsKlaus Kaluza, Olaf Mundigl, Thomas Kremer, Markus Britschgi, Sylwia Huber
Life of this patent
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Abstract
The invention provides anti-human alpha-synuclein antibodies and methods of using the same.
Claims8
An anti-human alpha-synuclein antibody, comprising six HVRs wherein:
- a) HVR-H1 comprises the amino acid sequence of SEQ ID NO:
- 08, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
- 09, HVR-H3 comprises the amino acid sequence of SEQ ID NO:
- 04, HVR-L1 comprises the amino acid sequence of SEQ ID NO:
- 10, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
- 11, and HVR-L3 comprises the amino acid sequence of SEQ ID NO:
- 12;
- or
- b) HVR-H1 comprises the amino acid sequence of SEQ ID NO:
- 21, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
- 22, HVR-H3 comprises the amino acid sequence of SEQ ID NO:
- 17, HVR-L1 comprises the amino acid sequence of SEQ ID NO:
- 23, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
- 24, and HVR-L3 comprises the amino acid sequence of SEQ ID NO:
- 25;
- or
- c) HVR-H1 comprises the amino acid sequence of SEQ ID NO:
- 28, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
- 34, HVR-H3 comprises the amino acid sequence of SEQ ID NO:
- 30, HVR-L1 comprises the amino acid sequence of SEQ ID NO:
- 35, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
- 36, and HVR-L3 comprises the amino acid sequence of SEQ ID NO:
- 37.
20 more elements
Dependencies are inferred from the claim text.