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US 10,647,759 B2Granted
Anti-N3pGlu amyloid beta peptide antibodies and uses thereof
AssigneeEli Lilly and Company
InventorsRonald Bradley Demattos, Jirong Lu, Ying Tang
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Abstract
Antibodies to human N3pGlu Aβ, compositions comprising such N3pGlu Aβ antibodies, and methods of using such N3pGlu Aβ antibodies for the treatment of a disease characterized by deposition of Aβ including clinical or pre-clinical Alzheimer's disease, Down's syndrome, and clinical or pre-clinical cerebral amyloid angiopathy.
Claims15
An antibody that binds human N3pGlu Aβ, comprising a light chain variable region (LCVR) and a heavy chain variable region (HCVR), wherein the LCVR comprises LCDR1 having the amino acid sequence of SEQ ID NO:
- 4, LCDR2 having the amino acid sequence of SEQ ID NO:
- 6, and LCDR3 having the amino acid sequence of SEQ ID NO:
- 8, and wherein the HCVR comprises HCDR1 having the amino acid sequence of SEQ ID NO:
- 1, HCDR2 having the amino acid sequence of SEQ ID NO:
- 2, and HCDR3 having the amino acid sequence of SEQ ID NO:
- 3.
3 more elements
Dependencies are inferred from the claim text.