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US 10,647,754 B2Granted
Stabilized single human CD4 domains and fusion proteins
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsDimiter S. Dimitrov, Weizao Chen, Prabakaran Ponraj
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Abstract
The invention provides a polypeptide comprising a single domain CD4, as well as a fusion protein comprising the single domain CD4 and one or more fusion partners. A nucleic acid encoding the polypeptide or fusion protein, as well as compositions or cells comprising the polypeptide, fusion protein, or nucleic acid also are provided.
Claims18
A composition comprising
- two fusion proteins each consisting essentially of SEQ ID NO:
- 21, and
- two fusion proteins each comprising SEQ ID NO:
- 20,
- wherein the two fusion proteins comprising SEQ ID NO:
- 20 are covalently bonded to each other, and
- wherein one of the fusion proteins consisting essentially of SEQ ID NO:
- 21 is covalently bonded to one of the fusion proteins comprising SEQ ID NO:
- 20, and the other of the fusion proteins consisting essentially of SEQ ID NO:
- 21 is covalently bonded to the other of the fusion proteins comprising SEQ ID NO:
- 20.
8 more elements
A composition comprising
- two fusion proteins each consisting essentially of SEQ ID NO:
- 21, and
- two fusion proteins each consisting essentially of SEQ ID NO:
- 20,
- wherein the two fusion proteins consisting essentially of SEQ ID NO:
- 20 are covalently bonded to each other, and
- wherein one of the fusion proteins consisting essentially of SEQ ID NO:
- 21 is covalently bonded to one of the fusion proteins consisting essentially of SEQ ID NO:
- 20, and the other of the fusion proteins consisting essentially of SEQ ID NO:
- 21 is covalently bonded to the other of the fusion proteins consisting essentially of SEQ ID NO:
- 20.
8 more elements
Dependencies are inferred from the claim text.