Cationic neurotoxins
AssigneeIpsen Bioinnovation Limited
InventorsDina Brady Anderson, Gavin Stephen Hackett, Sai Man Liu
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Abstract
Engineered clostridial toxins comprising an amino acid modification that increases the isoelectric point of the engineered clostridial toxin to a value that is at least 0.2 pI units higher than the isoelectric point of an otherwise identical clostridial toxin lacking the modification, wherein the modification is not located in the clostridial toxin binding domain (HC domain).
Claims18
An engineered clostridial toxin comprising an amino acid modification that increases the isoelectric point of the toxin to a value that is at least 0.2 pI units higher than the isoelectric point of an otherwise identical toxin lacking the modification, wherein the modification is not located in the clostridial toxin binding domain and the clostridial light chain does not contain an E3 ligase recognition motif.
An engineered clostridial toxin comprising an amino acid modification located in the clostridial toxin translocation domain that increases the isoelectric point of the toxin to a value that is at least 0.2 pI units higher than the isoelectric point of an otherwise identical toxin lacking the modification.
Dependencies are inferred from the claim text.