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US 10,647,747 B2Granted
Cyclosporin derivatives and uses thereof
AssigneeS&T Global Inc.
InventorsZhuang Su, Zhengyu Long, Zhennian Huang, Suizhou Yang
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Abstract
The present invention relates to a compound of the Formula (I)): or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, and hair loss.
Claims34
A compound of Formula (I):
- or pharmaceutically acceptable salt thereof, wherein:
- R8 is n-butyl, (E)-but-2-enyl,
- R2 is ethyl;
- W is O, S, or CH2;
- R3 is
- —(CH2)5—NRARB, or —(CH2)6—NRARB, wherein NRARB is selected from the group consisting of NH2, NMe2, NEt2, NH(iso-butyl), NMe(iso-butyl), NEt(iso-butyl), N(iso-butyl)2, NH(neopentyl), NMe(neopentyl), NEt(neopentyl), N(iso-butyl)(neopentyl), N(neopentyl)2,
- in which
- RC is H, Me, Et, n-Pr, i-Pr, n-Bu, i-Bu, t-Bu, or CH2CMe3;
- R7 is
- and
- R5 is H, (C1-C6)alkyl, (C2-C6)alkenyl, phenyl, benzyl, CH2—S—(C1-C6)alky, CH2—O—(C1-C6)alkyl, (C2-C6)alkylOH, or (C2-C6)alkylO(C1-C6)alkyl.
8 more elements
Dependencies are inferred from the claim text.