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US 10,647,746 B2Granted
Antibacterial cyclic lipopeptides
AssigneeVersitech Limited
InventorXuechen Li
Life of this patent
Estimating the term…
Abstract
Described are design and generation of a set of novel cyclic lipopeptides as potential antibacterial agents. New daptomycin analogues are generated by chemical synthesis, which makes introduction of an unnatural amino acid and any modification into daptomycin possible.
Claims13
A cyclic peptide of Formula IV:
- R1 is the side chain of Trp, N-alkylated Trp, or substituted 1- or 2-naphtylalanine;
- R2 is H or methyl;
- R3 is the side chain of an amino acid, natural or unnatural;
- R4 is H or methyl or ethyl;
- R5 is 1-1;
- R6 is methyl, ethyl, n-propyl, isopropyl, n-butyl, t-butyl, n-heptyl, or n-hexyl;
- X is O or NH;
- R is linear C9H19 or 4-phenylethynyl-phenyl of Formula II (Y is the substituent at any position of the aromatic ring)
- Y is H, or an alkyl, or aryl or alkenyl, or alkynyl, or carbonyl, or heteroalkyl, or heteroaryl, or heterocycle, or hydroxyl, or halogen, or nitro group.
6 more elements
A cyclic peptide of Formula IV:
- R1 is the side chain of Trp;
- R2 is H;
- R3 is the side chain of Orn;
- R4 is methyl;
- R5 is H;
- R6 is methyl, ethyl, n-pro isopropyl, n-butyl, t-butyl, n-heptyl, or n-hexyl;
- X is O;
- R is linear C9H19.
5 more elements
A cyclic peptide comprising the structure:
Dependencies are inferred from the claim text.