Heterocyclic compounds and uses thereof
AssigneePlexxikon Inc.
InventorsPrabha N. Ibrahim, Wayne Spevak, Jiazhong Zhang, Songyuan Shi, Ben Powell, Yan Ma
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Abstract
Provided herein are heterocyclic compounds of Formula (I), pharmaceutical compositions containing such a compound and their therapeutic uses, methods for their preparation, intermediate compounds, pharmaceutical compositions containing such a compound, and their therapeutic uses.
Claims6
A process of making compound 13:
- said process comprising contacting compound 12:
- with potassium tert-butoxide and iodomethane under conditions sufficient to form compound 13.
A process of making compound P-002:
- said process comprising contacting compound 13:
- with compound 13b:
- in the presence of [1,1′-Bis(diphenyl-phosphino)ferrocene]dichloropalladium(II) under conditions sufficient to form compound P-002.
A process of making a compound P-001:
- said process comprising contacting compound P-002:
- with lithium hydroxide under conditions sufficient to form compound P-001.
A compound of formula:
A method for treating acute myeloid leukemia comprising administering to a subject in need thereof an effective amount of a compound of formula:
- or a pharmaceutically acceptable salt thereof, and azacitidine.
A method for treating ovarian cancer comprising administering to a subject in need thereof an effective amount of a compound of formula:
- or a pharmaceutically acceptable salt thereof, and carboplatin.
Dependencies are inferred from the claim text.