Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors

A compound of formula (I), or a pharmaceutically acceptable salt thereof:

• wherein:
• n is 1;
• p is 1;
• each occurrence of A is —CH═;
• M is selected from —O— and —S—;
• R1 is
• pyridinyl;
• wherein the pyridinyl is optionally substituted with 1-3 substituents independently selected from:
• (a) halogen,
• (b) —C3-8 cycloalkyl, optionally substituted with OH,
• (c) —CN,
• (d) oxo,
• (e) —O—C1-8 alkyl, optionally substituted with 1-5 halogens,
• (f) —O—C3-8 cycloalkyl,
• (g) —C1-8 alkyl, optionally substituted with 1-4 substituents independently selected from halogen, —OH, —NH2, NHC(O)Rc and —S(O)2—C1-8 alkyl, wherein Rc is selected from —C1-8 alkyl and —C3-8 cycloalkyl,
• (h) —NH—S(O)2—Rc, wherein Rc is selected from —C1-8 alkyl and —C3-8 cycloalkyl,
• (i) —C(O)—Rf, Rf is selected from —OH, —NH2 and —NH—C1-8 alkyl,
• (j) aryl, optionally substituted with 1-3 halogens, and
• (k) heterocyclyl, optionally substituted with 1-3 substituents independently selected from halogen and —C1-8 alkyl;
• R2 is
• phenyl;
• wherein the phenyl is optionally substituted with 1-3 substituents independently selected from:
• (a) halogen,
• (b) —C3-8 cycloalkyl,
• (c) —CN,
• (d) —O—C1-8 alkyl, optionally substituted with 1-3 halogens and
• (e) —C1-8 alkyl, optionally substituted with 1-3 substituents independently selected from halogen, —OH and —NH2;
• and
• R3 is selected from H, halogen and —C1-8 alkyl, optionally substituted with —OH.