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US 10,647,704 B2Granted
Pharmaceutical compounds
AssigneeCellcentric GmbH & Co. KG
InventorsNeil Anthony Pegg, David Michel Adrien Taddei, Jonathan Shannon, Silvia Paoletta, Ting Qin, Gareth Harbottle
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Abstract
A compound which is a benzimidazole of formula (I): wherein X is a 5-membered heteroaryl group selected from the following: or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer.
Claims8
A compound which is a benzimidazole of formula (I):
- wherein:
- X is a 5-membered heteroaryl group selected from the following:
- R1 is a group which is unsubstituted or substituted and is selected from C-linked 4- to 6-membered heterocyclyl;
- C3-C6 cycloalkyl;
- C1-C6 alkyl which is unsubstituted or substituted by C6-C10 aryl, 5- to 12-membered N-containing heteroaryl, C3-C6 cycloalkyl, OH, —OC(O)R′ or OR′ wherein R′ is unsubstituted C1-C6 alkyl;
- and a spiro group of the following formula:
- Y is —CH2—, —CH2CH2— or —CH2CH2CH2—;
- n is 0 or 1;
- and
- R2 is a group selected from C6-C10 aryl, C5-C6 heteroaryl, C3-C6 cycloalkyl and C5-C6 cycloalkenyl, wherein the group is unsubstituted or substituted and wherein C6-C10 aryl is optionally fused to a 5- or 6-membered heterocyclic ring;
- or a pharmaceutically acceptable salt thereof.
8 more elements
Dependencies are inferred from the claim text.