3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof

A compound of Formula (Ic):

• or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof,
• wherein:
• each R1 is independently (C1-C6)alkyl;
• R2 is (C1-C6)alkyl substituted with one to three R4;
• each R4 is independently selected from phenyl or 5- or 6-membered heteroaryl comprising 1 to 4 heteroatoms selected from O, N, and S, wherein the phenyl and heteroaryl groups are optionally substituted with one to three R7;
• each R7 is independently selected from (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxy, —C(O)R8, —C(O)OR8, —C(O)NR8R9, —NR8C(O)R9, (C1-C6)hydroxyalkyl, halogen, —OH, —NH2, CN, (C6-C10)aryl, 5- or 6-membered heteroaryl comprising 1 to 3 heteroatoms selected from O, N, and S, (C3-C7)cycloalkyl, and 5- to 7-membered heterocycloalkyl comprising 1 to 3 heteroatoms selected from O, N, and S, or
• two R7, when on adjacent atoms, together with the atoms to which they are attached form a (C6-C10)aryl ring or a 5- or 6-membered heteroaryl ring comprising 1 to 3 heteroatoms selected from O, N, and S, optionally substituted with one or more R10, or
• two R7, when on adjacent atoms, together with the atoms to which they are attached form a (C5-C7)cycloalkyl ring or a 5- to 7-membered heterocycloalkyl ring comprising 1 to 3 heteroatoms selected from O, N, and S, optionally substituted with one or more R10;
• R8 and R9 are each independently H or (C1-C6)alkyl;
• each R10 is independently selected from (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxy, (C1-C6)hydroxyalkyl, halogen, —OH, —NH2, and CN;
• and
• q is 0.