Substituted benzimidazoles and benzopyrazoles as CCR(4) antagonists

A method of treating a disease or condition mediated by CCR(4) signaling, said method comprising administering to a subject in need thereof an efficacious amount of a compound of formula (I):

• or a pharmaceutically acceptable salt thereof wherein:
• R1 is a member selected from the group consisting of hydrogen, C1-8 alkyl, C1-8 haloalkyl, C3-8 cycloalkyl, and halogen;
• R2 is a member selected from the group consisting of hydrogen, C1-8 alkyl, C3-8 cycloalkyl, C1-8 haloalkyl, halogen, CN and C1-8 haloalkyl;
• R3 is a member selected from the group consisting of H, C1-4 lower alkyl and C1-4 haloalkyl;
• R4 is a member selected from the group consisting of H, C1-8 alkyl, C1-8 haloalkyl, C1-8 hydroxyalkyl and ═O;
• the subscripts n are each independently selected from the group consisting of 0, 1, 2 and 3;
• the subscript m is 0 or 1;
• each A is independently C or N, and at least one A is N;
• B is a member selected from the group consisting of a bond, C(O), C(O)NH, C(O)NRa, CH2C(O)NH, CH2C(O)NRa, NH and NRa;
• Q is a member selected from the group consisting of C, CH, N, O, S, S(O) and SO2;
• W and Z are independently C, CH, or N with the exception that Q and W may not be N in the same molecule;
• Y is C or CH;
• R5 and R6 are each independently absent or are a member selected from the group consisting of H, OH, halogen, C1-8 alkyl, C1-8 hydroxyalkyl, C1-8 alkoxy, and C1-8 alkyl-NH2;
• R7 is absent or a member selected from the group consisting of H, halogen, C1-8 alkyl and C1-8 haloalkyl;
• R8 is absent or a member selected from the group consisting of H, OH, NH2, NHRa, CN, C1-4 aminoalkyl, C1-4 hydroxy alkyl and C1-4 alkyl;
• R9 is absent or a member selected from the group consisting of H, C1-4 alkyl, C1-8 haloalkyl, CN, and —CO2Ra;
• R10 is absent or a member selected from the group consisting of H, CF3, C1-4 alkyl and CN;
• and wherein
• Ra is selected from the group consisting of H and C1-8 alkyl;
• wherein said disease or condition is selected from the group consisting of allergic diseases, inflammatory bowel disease, vaginitis, psoriasis, inflammatory dermatoses, vasculitis, spondyloarthropathies, scleroderma, asthma, respiratory allergic diseases, systemic lupus erythematosus, lymphoma and renal cancer.