Compounds and compositions for the inhibition of NAMPT

A compound of Formula IIIA:

• wherein:
• Ra is present 1, 2, 3, or 4 times, and each Ra is independently selected from the group consisting of hydrogen, amino, oxo, halo, alkoxy, alkyl, haloalkyl, —N(alkyl)2, —NH(CO)O-alkyl, 1H-pyrazole, 1H-imidazole, and C(O)NH2;
• the pyridine to which Ra is attached can comprise a N-oxide formed with its N atom member;
• R1 is NR3R4;
• R3 is H, alkyl or —S(O)2alkyl;
• R4 is —(CH2)qheteroaryl;
• wherein said heteroaryl of R4 is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents which can be the same or different and are independently selected from the group consisting of:
• halo, cyano, alkyl, hydroxyl, hydroxyalkyl, hydroxyalkoxy, haloalkyl, alkoxy, alkylalkoxy, haloalkoxy, arylalkenyl-, aryloxy, benzyloxy, oxo, —(CH2)q—NRbRc, —(CH2)q—CONRbRc, —S(O)2-alkyl, —S(O)2NH-alkyl, —S(O)2-heterocycloalkyl, —S(O)2—CF3, —C(O)alkyl, —C(O)aryl, —C(O)alkylenylaryl, —C(O)O-alkyl, —(CH2)qcycloalkyl, cycloalkylalkoxy-, aryl, arylalkyl-, —(CH2)qheteroaryl, and —(CH2)qheterocycloalkyl;
• wherein each of said cycloalkyl, heterocycloalkyl, aryl, or heteroaryl may be substituted by one or more halo, nitro, haloalkyl, haloalkoxy, oxo, cyano, alkyl, haloalkyl, or alkoxy;
• Rb and Rc are independently selected from the group consisting of H, alkyl, hydroxyalkyl, alkoxy, aryl, alkoxyalkyl, —S(O)2alkyl and cycloalkyl;
• or Rb and Rc can form a 5 or 6 membered heterocycloalkyl group together with the nitrogen atom to which they are attached, wherein said heterocycloalkyl group may contain one or more additional heteroatom(s) selected from the group consisting of N, S and O;
• and
• q is 0 or 1;
• or a pharmaceutically acceptable salt thereof.