2,3-epoxy succinyl derivative, preparation method and use thereof

A compound represented by Formula (1), a racemate or an optical isomer thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof,

• wherein,
• R1 represents a hydrogen atom, C1-C10 linear or branched alkyl, C3-C10cycloalkyl, C2-C10 linear or branched alkenyl, C2-C10 linear or branched alkynyl;
• R2 represents a hydrogen atom, C1-C10 linear or branched alkyl, C3-C10cycloalkyl, C2-C10 linear or branched alkenyl, C2-C10 linear or branched alkynyl, phenyl, phenyl-C1-C6alkyl, optionally, wherein the C1-C10 linear or branched alkyl, C3-C10cycloalkyl, C2-C10 linear or branched alkenyl, C2-C10 linear or branched alkynyl, phenyl, or phenyl-C1-C6alkyl each is independently substituted with one or more substituents selected from the group consisting of:
• halogen, amino, cyano, trifluoromethyl, hydroxyl, nitro, C1-C10alkyl, C1-C10alkoxy and C1-C10alkylthio, optionally, wherein the C1-C10alkyl, C1-C10alkoxy or C1-C10alkylthio is further substituted with one or more substituents selected from the above-mentioned group;
• X represents —O—, or —N(R5)—;
• n is an integer from 0 to 5;
• R3 and R4 each independently represent a hydrogen atom, C1-C10 linear or branched alkyl, C3-C10cycloalkyl, phenyl, or phenyl-C1-C6alkyl, optionally, wherein the C1-C10 linear or branched alkyl, C3-C10cycloalkyl, phenyl, or phenyl-C1-C6alkyl each is independently substituted with one or more substituents selected from the group consisting of:
• halogen and C1-C10alkyl, optionally, wherein the C1-C10alkyl is further substituted with one or more substituents selected from the above-mentioned group;
• or,
• R3 and R4, together with the N atom to which they are linked, form a 5-8 membered heterocycle, and the 5-8 membered heterocycle is piperidine, tetrahydropyrrole or tetrahydrothiazole, optionally, the 5-8 membered heterocycle is substituted with one or more substituents selected from the group consisting of:
• halogen, hydroxyl, amino, C1-C10alkyl, C1-C10alkoxy, C1-C10alkylthio, phenyl, oxy and ester group;
• R5 represents a hydrogen atom, or C1-C10 linear or branched alkyl.